A 90 Day, double-blind, randomized placebo-controlled study to evaluate the efficacy and safety of Boswellia Serrata in the treatment of osteoarthritis of the knee (knee pain). Boswellia serrata significantly improved joint function and exhibited better therapeutic efficacy at 250mg/day than at 100mg/day; it reduces pain rapidly, as early as after 1 week of treatment; it reduces levels of the cartilage degrading enzyme MMP-3 in synovial fluid; and most importantly, boswellia is safe for human consumption, even long term.
source: sengupta K, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin (R) for treatment of osteoarthritis of the knee. Arthritis Res Ther 2008: 10:R85.
Another supplement to consider in the treatment of knee pain is Glucosamine and chondroitin sulfate. However, it should be mentioned that studies suggest that it works better in patients with osteoarthritis of the knee with a normal body mass index (BMI). Many people have wrongfully thought that the benefit of glucosamine sulfate stemmed from an enhancement in cartilage synthesis. This notion ignores the anti-inflammatory effects of glucosamine while exaggerating the cartilage synthesis benefits according to David Seaman DC.